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An experimental drug could help to improve movement for patients with spinal cord injuries.
NVG-291, an injectable peptide, has been tested in a phase 2 trial with eligible patients — some of whom noted remarkable outcomes.
Larry Williams, a trial participant based in Philadelphia, Pennsylvania, shared with Fox News Digital that he’s been able to walk again after an accident that caused paralysis.
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Williams, 58, was mountain biking on a small trail when he struck a tree. Although he was wearing a helmet, he “instantly broke” his C4 to C6 vertebrate (specific bones in the cervical spine).
He underwent spinal surgery, but was paralyzed for two weeks until his body began to “wake up” and regained some movement after starting therapy.
Larry Williams of Philadelphia (pictured) survived a mountain biking accident that left him paralyzed. (Larry Williams)
Williams was able to walk “a little bit” with the assistance of a walker, but still had complications with mobility in areas like his hands. He also lost 40 pounds after the accident.
After some research, he discovered the NVG-291 trial and was considered a viable candidate, he told Fox News Digital.
For three months, starting in April 2024, Williams received a daily injection of the drug followed by one hour of physical therapy, which included hand exercises and walking with a harness on a flat track or treadmill.
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Williams also underwent blood tests and electrophysiological testing to measure the electrical activity of his nerves and muscles, as well as physical testing once a month.
At the end of the trial, Williams reported that he was able to walk 10 meters (32.8 feet), balanced with a walker, in 15 seconds, an improvement over 45 seconds.
Although he has not received the drug since July 2024, Williams continues to see physical improvements over a year later.
Larry Williams joined the NVG-291 trial as a spinal cord injury patient in April 2024. (Larry Williams; iStock)
“I’m not working out really hard. I’m currently not in therapy,” he told Fox News Digital. “But just a couple of days ago, I stood up and tried to free-stand, balance and lift one foot off the ground. I was able to do it for 30 seconds.”
“I hadn’t been practicing this. I can’t explain how it happened,” he added. “There are small improvements that continue to happen.”
Williams said he had tried the same maneuver six months earlier and couldn’t hold his foot off the ground for even three seconds.
“There are small improvements that continue to happen.”
Since the trial, Williams has continued to improve his walking ability, and can even swim laps in the pool.
“I reach out to other people with the same injury as me, and it seems like a lot of them, after years and years of therapy, get to where I am,” he said. “And it kind of seems like I’ve been given a shortcut … I would love to get to the life that I had before, being fully independent.”
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After taking the experimental drug, Williams said he has been able to perform physical tasks “easily and quickly.”
“The movement in my legs seems to be a little bit smoother and less restricted as the time passed by,” he said. “I’m not going to give up. I’m going to keep pushing and trying.”
How the drug works
In a separate interview with Fox News Digital, lead researcher Dr. Monica Perez, scientific chair at the Shirley Ryan AbilityLab in Chicago and professor of physical medicine and rehabilitation at Northwestern University, said the drug was first tested on animals, which displayed improved locomotor function (movement).
The researchers then conducted a randomized clinical trial in humans, in which half of the participants received the NVG-291 drug, which contained a repair molecule to improve nervous system function.
NVG-291 is a peptide drug that contains a repair molecule to improve nervous system function. (iStock)
The drug is a peptide, which is a small protein that works like a roadblock remover. After a spinal cord injury, the body sends out signals that tell nerve fibers to stop growing. This drug blocks those signals, so the nerves have a better chance to regrow.
“This peptide can block those inhibitory signals,” Ryan said. “There is a little bit of evidence in animals that it can actually enhance the growth of neurons.”
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Although GLP-1 receptor agonists, best known for weight loss and diabetes treatment, are a peptide, Perez said this spinal cord injury treatment works differently.
“It has a specific mechanism, and it’s more related to repair, to try to enhance the growth of neurons that are affected by central nervous system injury,” she said.
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Spinal cord injuries are typically approached with cell therapies, like stem cells and bone marrow stromal cells, Perez noted.
This peptide approach, in contrast, is “easy to administer,” can be done at home, achieves a “similar goal” and is “extremely safe,” she added.
Researchers observed “electrophysiological changes” in the group that received the experimental medication. (iStock)
Perez said more research is necessary to determine how long the effects of this drug will last.
“We observed strong electrophysiological changes in the group that received the medication compared to the placebo group, but we don’t have follow-up measurements,” she said. “There’s no way for us to understand the real duration of these treatments.”
As there is not currently an FDA-approved treatment for spinal cord injuries, Perez said that those involved with this research are “very devoted” to advancing this science.
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While each patient may react differently, Williams said he would recommend this treatment to other people with spinal cord injuries.
“It could really change things for people with injuries like mine,” he said. “I’m just praying that everybody out there is able to have an opportunity to gain back their life.”
